| Gene Symbol | SPTLC1 |
| Full Name | Serine Palmitoyltransferase Long Chain Base Subunit 1 |
| Aliases | Page for SPTLC1, Serine Palmitoyltransferase 1 |
| Chromosome | 9q22.31 |
| Protein Type | Gene |
| Target Class | Protein |
| Function | The canonical reaction catalyzed by SPT involves the condensation of L-serine with palmitoyl-CoA (C16:0) to produce 3-ketosphinganine, which is subsequently reduced to sphinganine (dihydrosphingosine) |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: APOE-Mediated Synaptic Lipid Raft Stabilization |
| Druggability | Undruggable (0.23) |
| Molecular Weight | 53 kDa |
| Amino Acids | 473 aa |
| Pathways | Cholesterol, Sphingolipid biosynthesis, Sphingolipid metabolism |
| UniProt ID | O15269 |
| GeneCards | SPTLC1 |
| Human Protein Atlas | SPTLC1 |
| Associated Diseases | Als, Amyotrophic lateral sclerosis, disease, Early-Onset Motor Neuron Disease |
| Known Drugs/Compounds | CHEMBL1241090, CHEMBL4584997, CHEMBL4541898 |
| Interactions | ABCA1, Actin, ALS, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, APOE4 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | APOE-Mediated Synaptic Lipid Raft Stabilization |
| KG Connections | 212 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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