gene 2,857 words KG: SLC17A6
Contents

SLC17A6 Gene

🧬 Gene Info
Gene SymbolSLC17A6
Full NameSolute Carrier Family 17 Member 6
AliasesVGLUT2
Chromosome11q14.1
Protein TypeTransporter
Functionis a critical vesicular glutamate transporter responsible for packaging glutamate into synaptic vesicles at excitatory synapses.
Primary Expressionspecific neuronal populations:
Molecular Weight64 kDa
Amino Acids582 aa
Exons16
PathwaysEpigenetic, Synaptic Plasticity, Synaptic Vesicle, autophagy pathway
UniProt ID[Q9P2U7](https://www.uniprot.org/uniprot/Q9P2U7)
Ensembl IDENSG00000164690
GeneCardsSLC17A6
Human Protein AtlasSLC17A6
Associated DiseasesAls, Cancer, Tumor
Interactions6-OHDA, AMPK, AND, ATG5, BECN1, CAMK2
KG Connections171 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Sex differences in CB1R-mediated cannabinoid analgesia in ne
validation · proposed · Score: 0.90
Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85

See Also (12)

Astrocytes
cell · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Astrocytes
entity · KG edge: expressed_in
Genes
index · KG edge: associated_with
ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1
gene · KG edge: inhibits

Knowledge Graph (12 edges)

ERK1 inhibits SLC17A6
SLC17A6 associated_with VGLUT2
SLC17A7 biomarker_for SLC17A6
SLC17A6 biomarker_for SLC12A5
SLC17A6 biomarker_for SYN2
SLC17A6 biomarker_for GAD1
SLC17A6 biomarker_for SYP
SLC17A6 biomarker_for SLC32A1
SLC17A6 biomarker_for GRIN2A
SLC17A6 biomarker_for PVALB

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