gene 914 words KG: GAD1
Contents

Glutamate Decarboxylase 1

🧬 Gene Info
Gene SymbolGAD1
Full NameGlutamate Decarboxylase 1
Chromosome2q31.1
Protein TypeReceptor
FunctionIt plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expressionregions affected in Parkinson disease
PathwaysMapk, autophagy pathway
UniProt IDP23284
NCBI Gene ID2571
Ensembl IDENSG00000118592
OMIM605119
GeneCardsGAD1
Human Protein AtlasGAD1
Associated Diseasesepilepsy
Known Drugs/Compoundsrapamycin
InteractionsAMPK, APP, ASTROCYTES, Bdnf, BDNF, CALB1
KG Connections184 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
APOE-Dependent Autophagy Restoration
Score: 0.88
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (3)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (4)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Astrocytes
entity · KG edge: expressed_in
BDNF Gene
gene · KG edge: associated_with
CALB1 (Calbindin 1)
gene · KG edge: inhibits

Knowledge Graph (12 edges)

APP co_discussed GAD1
GAD1 co_discussed PSEN1
SLC17A7 biomarker_for GAD1
SLC17A6 biomarker_for GAD1
SLC12A5 biomarker_for GAD1
SYN2 biomarker_for GAD1
GAD1 biomarker_for SYP
GAD1 biomarker_for SLC32A1
GAD1 biomarker_for GRIN2A
GAD1 biomarker_for PVALB

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.