gene 1,524 words KG: NEUROG1
Contents

NEUROG1 (Neurogenin-1)

🧬 Gene Info
Gene SymbolNEUROG1
Full NameNeurogenin-1
Chromosome9q34.3
Protein TypeTranscription Factor
Functionis a Class A basic helix-loop-helix (bHLH) transcription factor that functions as a potent proneural gene essential for the development of specific neuronal populations.
Amino Acids237 aa
Exons2
PathwaysEpigenetic, epigenetic regulation, oxidative stress response
UniProt IDQ96TT8
NCBI Gene ID4744
Ensembl IDENSG00000181965
OMIM605526
GeneCardsNEUROG1
Human Protein AtlasNEUROG1
Preferred motifCACCTG, CAGCTG
Associated Diseasesneurodegeneration
InteractionsAPC, ARID1A, CANCER, KRAS, P53, PMS2
KG Connections46 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (8)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Arginine Methylation Enhancement Therapy
Score: 0.65

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (9)

DNA Methylation
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: biomarker_for
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
APC Gene
gene · KG edge: activates
ARID1A
gene · KG edge: activates

Knowledge Graph (12 edges)

CDKN2A biomarker_for NEUROG1
ARID1A activates NEUROG1
NEUROG1 activates TP53
NEUROG1 activates APC
NEUROG1 biomarker_for MLH1
NEUROG1 activates PMS2
NEUROG1 biomarker_for CACNA1G
APC activates NEUROG1
TP53 activates NEUROG1
PMS2 activates NEUROG1

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