gene 944 words KG: NCOA1
Contents

NCOA1 Gene

🧬 Gene Info
Gene SymbolNCOA1
Full NameNuclear Receptor Coactivator 1
Chromosome2p23.3
Protein TypeReceptor
Functionis a member of the p160 family of nuclear receptor coactivators[@ncoa2000].
Primary Expressionthe brain and has been implicated in various neurological processes including neuroprotection, synaptic plasticity, and neurodegenerative disease path
Molecular Weight164 kDa
Amino Acids1459 aa
UniProt IDQ15788
NCBI Gene ID8644
Ensembl IDENSG00000084676
OMIM602071
GeneCardsNCOA1
Human Protein AtlasNCOA1
Associated Diseasesneurodegeneration
InteractionsEGFR, HIF1A, RELA
KG Connections9 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (15)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
CYP46A1 Overexpression Gene Therapy
Score: 0.98
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: inhibits
ESR1 — Estrogen Receptor Alpha
gene · KG edge: therapeutic_target
FOS Gene
gene · KG edge: therapeutic_target
HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha
gene · KG edge: inhibits

Knowledge Graph (9 edges)

FOS therapeutic_target NCOA1
RELA inhibits NCOA1
EGFR inhibits NCOA1
NCOA1 inhibits HIF1A
NCOA1 therapeutic_target HSP90AA1
NCOA1 therapeutic_target ESR1
NCOA1 therapeutic_target CANCER
NCOA1 therapeutic_target Ms
NCOA1 therapeutic_target Cancer

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