gene 749 words KG: LIFR
Contents

LIFR - Leukemia Inhibitory Factor Receptor

🧬 Gene Info
Gene SymbolLIFR
Full NameLeukemia Inhibitory Factor Receptor
AliasesPage for LIFR
Chromosome5p13.1
Protein TypeGene
FunctionLIFR forms a signaling complex with gp130 (IL6ST)
PathwaysPI3K, MAPK, NF-κB, Wnt signaling
UniProt IDP15090
NCBI Gene ID3977
GeneCardsLIFR
Human Protein AtlasLIFR
Official SymbolLIFR
Official Full NameLeukemia Inhibitory Factor Receptor Alpha
ProteinLIF Receptor Alpha
LIF bindingHigh-affinity interaction with LIFR
Associated Diseasesgastric cancer, neurodegeneration, renal interstitial fibrosis
InteractionsBDNF, BRD4, CANCER, EP300, JAK1, LIF
KG Connections32 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (8)

GFAP (Redirect)
redirect · KG edge: expressed_in
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
BDNF Gene
gene · KG edge: activates
BRD4 (Bromodomain-Containing Protein 4)
gene · KG edge: activates
EP300 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

LIFR activates JAK1
STAT3 activates LIFR
LIFR expressed_in GFAP
LIFR expressed_in LIF
GFAP expressed_in LIFR
LIF expressed_in LIFR
LIFR activates STAT3
SOX2 activates LIFR
LIFR activates LIF
LIFR activates EP300

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