gene 1,058 words KG: LIF
Contents

LIF — Leukemia Inhibitory Factor

🧬 Gene Info
Gene SymbolLIF
Full NameLeukemia Inhibitory Factor
AliasesPage for LIF Receptor Protein
Chromosome5p13.1
FunctionThe LIF gene encodes a 202-amino acid secreted glycoprotein that acts as a multifunctional cytokine:
Molecular Weight190 kDa
Amino Acids202 aa
Exons20
PathwaysMAPK, PI3K
UniProt IDP15018
NCBI Gene ID3977
Ensembl IDENSG00000128342
OMIM159446
GeneCardsLIF
Human Protein AtlasLIF
Associated Diseasesmultiple sclerosis
InteractionsActin, AND, App, ASTROCYTE, ASTROCYTES, BDNF
KG Connections125 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Phase-Separated Organelle Targeting
Score: 0.73
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: activates
GFAP (Redirect)
redirect · KG edge: expressed_in
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates

Knowledge Graph (12 edges)

LIF activates EGFR
LIF protects_against neurite damage
EGFR activates LIF
STAT3 activates LIF
LIFR expressed_in LIF
GFAP expressed_in LIF
LIF expressed_in LIFR
LIF activates STAT3
SOX2 activates LIF
LIFR activates LIF

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