gene 1,523 words KG: LGMN
Contents

LGMN Gene

🧬 Gene Info
Gene SymbolLGMN
Full NameLegumain (Asparagine Endopeptidase)
AliasesLegumain
Chromosome14q32.12
Protein TypeCysteine protease, peptidase family C13
FunctionThe structure features
Primary ExpressionUbiquitous, high in kidney, brain, immune cells
Subcellular Localization3:
Molecular Weight56 kDa
PathwaysAutophagy, Chaperone, Ferroptosis
UniProt IDQ99538
NCBI Gene ID5648
Ensembl IDENSG00000100600
OMIM607216
GeneCardsLGMN
Human Protein AtlasLGMN
Associated Diseasesneurodegeneration
InteractionsAGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, AUTOPHAGY
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
CTSD — Cathepsin D
gene · KG edge: associated_with
GPX4 Gene - Glutathione Peroxidase 4
gene · KG edge: activates

Knowledge Graph (12 edges)

LGMN interacts_with HK2
LGMN associated_with SQSTM1
LGMN associated_with KEAP1
LGMN associated_with CTSD
GPX4 activates LGMN
AKT activates LGMN
GBM activates LGMN
STAT3 activates LGMN
GBM regulates LGMN
LGMN activates STAT3

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