gene 931 words KG: KDM1A
Contents

KDM1A (Lysine Specific Demethylase 1A)

🧬 Gene Info
Gene SymbolKDM1A
Full NameLysine Specific Demethylase 1A
AliasesLysine Specific Demethylase 1A (LSD1
Chromosome1p36.22
Protein FamilyLSD1 family (Flavin-dependent amine oxidase)
Functionis a crucial epigenetic regulator that catalyzes the removal of methyl groups from histone lysine residues.
PathwaysFerroptosis, bone metabolism, epigenetic regulation
UniProt IDO60341
NCBI Gene ID23028
Ensembl IDENSG00000136867
OMIM607042
GeneCardsKDM1A
Human Protein AtlasKDM1A
H3K4me1/2Primary repressive target — removal activates gene expression
H3K9me1/2Primary activating target — removal represses gene expression
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Neurodevelopmental Disorders
InteractionsEP300, FERROPTOSIS, HDAC2, KDM6A, SLC7A11
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
← Prevpg 2/2

Related Analyses (2)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Notch and Gamma-Secretase Modulators for Parkinson's Di
company · KG edge: therapeutic_target
Neurodegeneration
disease · KG edge: implicated_in
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: therapeutic_target
Tumor Necrosis Factor (TNF)
entity · KG edge: inhibits
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: inhibits

Knowledge Graph (12 edges)

KDM1A activates SLC7A11
KDM1A inhibits HDAC2
KDM1A therapeutic_target DNMT1
KDM1A therapeutic_target EHMT2
KDM1A inhibits EP300
KDM1A regulates bone metabolism
KDM1A activates KDM6A
KDM6A targets KDM1A
KDM1A regulates CANCER
KDM1A activates FERROPTOSIS

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