| Gene Symbol | GAA |
| Full Name | Acid Alpha-Glucosidase |
| Chromosome | 17q25.2-q25.3 |
| Protein Type | Enzyme |
| Function | The GAA enzyme (acid alpha-glucosidase, also called acid maltase) is a lysosomal hydrolase that catalyzes the breakdown of glycogen to glucose. |
| Pathways | Amyloid, Apoptosis, Oxidative Stress, blood-brain barrier |
| UniProt ID | P10276 |
| NCBI Gene ID | 2548 |
| Ensembl ID | ENSG00000171298 |
| OMIM | 232300 |
| GeneCards | GAA |
| Human Protein Atlas | GAA |
| Substrate | Glycogen (α-1,4-linked glucose polymer) |
| Product | Glucose |
| Optimal pH | ~4.0-5.0 (acidic, lysosomal environment) |
| Associated Diseases | neurodegeneration |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOPTOSIS, APP |
| KG Connections | 71 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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