| Gene Symbol | DRD4 |
| Chromosome | 11p15.5 |
| Function | is a 48-base pair VNTR in exon 3, which can vary from 2 to 11 repeats[@van1993]. |
| Primary Expression | brain regions involved in executive function, attention, and reward processing, including the prefrontal cortex, [ |
| Molecular Weight | 55 kDa |
| Pathways | dopaminergic_circuits |
| Ensembl ID | ENSG00000169605 |
| GeneCards | DRD4 |
| Human Protein Atlas | DRD4 |
| MAPK activation | ERK1/2 phosphorylation |
| Receptor internalization | Clathrin-mediated endocytosis |
| Desensitization | GRK-mediated phosphorylation |
| Associated Diseases | Addiction, Opioid, SUD |
| Interactions | BDNF, DRD2, NEURODEGENERATION, NEUROINFLAMMATION, NEURON, OPRM1 |
| KG Connections | 72 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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