| Gene Symbol | DNAJB1 |
| Protein Type | Chaperone |
| Target Class | Chaperone |
| Function | DNAJB1 serves multiple essential cellular functions: |
| Mechanism of Action | Allosteric modulation of protein-protein interactions with Hsp70 |
| Subcellular Localization | **Cytosol**: Predominant localization |
| Druggability | Low (0.35) |
| Clinical Stage | Phase I |
| Molecular Weight | 38 kDa |
| Amino Acids | 340 aa |
| Pathways | Chaperone, Complement, Lysosomal Degradation, Oxidative Stress |
| UniProt ID | M0QXK0 |
| Ensembl ID | ENSG00000132002 |
| GeneCards | DNAJB1 |
| Human Protein Atlas | DNAJB1 |
| Associated Diseases | Als, Alzheimer, Diabetes, Ms, neurodegeneration |
| Known Drugs/Compounds | 115-7c, MAL3-101 |
| Interactions | Alpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, APOE4, ASTROCYTE |
| SciDEX Target | View Target Profile (5 clinical trials) |
| KG Connections | 237 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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