| Gene Symbol | COMT |
| Full Name | Catechol-O-Methyltransferase |
| Chromosome | 22 |
| Protein Type | Enzyme |
| Function | The COMT gene encodes catechol-O-methyltransferase, an enzyme that catalyzes the methylation of catecholamines using S-adenosylmethionine (SAM) as a methyl donor. |
| Primary Expression | peripheral tissues |
| Molecular Weight | 30 kDa |
| Pathways | autophagy pathway |
| UniProt ID | P21964 |
| Ensembl ID | ENSG00000093072 |
| OMIM | 116790 |
| GeneCards | COMT |
| Human Protein Atlas | COMT |
| Associated Diseases | age-related cognitive decline, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | levodopa, LEVODOPA |
| Interactions | ANKK1, APOE, BDNF, CYP2C18, CYP3A5, DAT |
| KG Connections | 291 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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