| Gene Symbol | CDNF |
| Full Name | Cerebral Dopamine Neurotrophic Factor |
| Chromosome | 10p13 |
| Protein Family | MANF/CDNF family |
| Function | CDNF performs several critical functions in the nervous system: |
| Primary Expression | the central nervous system, with particularly high expression in dopaminergic regions including the substantia nigra and striatum |
| Amino Acids | 60 aa |
| UniProt ID | [Q96GS4](https://www.uniprot.org/uniprot/Q96GS4) |
| GeneCards | CDNF |
| Human Protein Atlas | CDNF |
| N-terminal domain (1-60 aa) | Contains an ER retention signal sequence (RSNL) that directs protein to the endoplasmic reticulum. This region is involved in protein-protein interactions and ER homeostasis. |
| C-terminal domain (61-182 aa) | The secreted portion contains the neurotrophic activity and mediates receptor interactions on target neurons. |
| Associated Diseases | ALS, Alzheimer, Parkinson |
| Known Drugs/Compounds | levodopa |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, PARKINSON, PARKINSON'S DISEASE |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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