gene 1,028 words KG: ATP5A1
Contents

ATP5A1 Gene

🧬 Gene Info
Gene SymbolATP5A1
Full NameATP Synthase Subunit Alpha
Chromosome21q21.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight60 kDa
Amino Acids553 aa
UniProt ID[P25788](https://www.uniprot.org/uniprot/P25788)
Ensembl IDENSG00000188039
GeneCardsATP5A1
Human Protein AtlasATP5A1
Protein Size553 amino acids, ~60 kDa
TopologyMatrix-facing F1 domain
Oligomeric StateForms part of the alpha3beta3 hexamer with 3 alpha (ATP5A1) and 3 beta (ATP5B) subunits
Post-translational ModificationsKnown to be phosphorylated and acetylated, affecting enzyme activity and assembly
Associated Diseasesneurodegeneration
InteractionsACO2, ACTB, ACTG1, AIFM1, ATP, CALCOCO2
KG Connections80 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

SNAP-25
biomarker · KG edge: interacts_with
Parkinson Basal Ganglia Circuit
circuit · KG edge: therapeutic_target
Neurodegeneration
disease · KG edge: implicated_in
GFAP (Redirect)
redirect · KG edge: interacts_with
SOD1 (Redirect)
redirect · KG edge: interacts_with

Knowledge Graph (12 edges)

CCT2 interacts_with ATP5A1
GFAP interacts_with ATP5A1
GRIA1 interacts_with ATP5A1
SNAP25 interacts_with ATP5A1
ACTG1 interacts_with ATP5A1
SNCA interacts_with ATP5A1
GAPDH interacts_with ATP5A1
MAPK1 interacts_with ATP5A1
PSMA3 interacts_with ATP5A1
SOX2 interacts_with ATP5A1

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