gene 587 words KG: PRDM2
Contents

PRDM2 — PR/SET domain 2

🧬 Gene Info
Gene SymbolPRDM2
Full NamePRDI-BF1 and RIZ Homology Domain Containing 2
Protein FamilyPRDM Family
Protein TypeTransferase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationNucleus
Molecular Weight59 kDa
UniProt IDQ15691
GeneCardsPRDM2
Human Protein AtlasPRDM2
Alzheimer's DiseaseAltered expression and function contributes to epigenetic dysregulation of neuronal survival genes
Parkinson's DiseaseMay affect dopaminergic neuron survival through transcriptional mechanisms
Huntington's DiseaseInvolved in transcriptional dysregulation caused by mutant huntingtin protein
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

Related Hypotheses (5)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: expressed_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: expressed_in
Genes
index · KG edge: contributes_to
ARID1A
gene · KG edge: contributes_to

Knowledge Graph (12 edges)

ASH1L contributes_to PRDM2
ARID1A contributes_to PRDM2
PI3K expressed_in PRDM2
PRDM2 contributes_to EP300
PRDM2 expressed_in DNA
PRDM2 expressed_in P53
PRDM2 expressed_in CANCER
PRDM2 contributes_to GENES
PRDM2 expressed_in Colorectal Cancer
PRDM2 expressed_in Cancer

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...