Contents

Total Tau (t-Tau) - Biomarker

🔬 Protein Info

Gene Symbol	TAU
Chromosome	17q21.31
Protein Family	MAPT family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, where they bind to microtubules and promote their polymerization and stability
Subcellular Localization	Axons, Neurons
Molecular Weight	45-65 kDa (isoform dependent)
Amino Acids	441 aa
Pathways	Extracellular Aggregation, Hyperphosphorylation, Neurofibrillary Tangle Formation, Protein Assembly, Synapse Pathology
GeneCards	TAU
Human Protein Atlas	TAU
Microtubule stabilization	tau binds to tubulin to promote microtubule assembly and stability
Axonal transport	facilitates vesicle and organelle trafficking along axons
Neuronal polarity	contributes to axon initial segment integrity
CSF t-tau	<300 pg/mL (age-dependent; higher in elderly individuals over 70 years)
Associated Diseases	ALZHEIMER, alzheimers_disease, Alzheimer's disease, apoptosis, frontotemporal_dementia, hippocampal atrophy
Known Drugs/Compounds	EGCG, rutin, Urolithin A
Interactions	Amyloid-β, APOE4, ASK1, Aβ, CDK5, GSK-3β
KG Connections	121 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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