| Gene Symbol | PD |
| Reaction mixture | Contains recombinant alpha-synuclein monomer (substrate), Thioflavin T (fluorescent dye), and NaCl |
| Cycling conditions | Alternating periods of shaking (1 min) and rest (1 min) at 30°C for 30-100 hours |
| Detection | Thioflavin T fluorescence measured every 15-30 minutes |
| Positive response | Seed-induced aggregation causes increased fluorescence |
| Sensitivity | Can detect as few as 10-100 aggregated alpha-synuclein seeds[@okuzumi2023] |
| Advantages | Extremely high sensitivity, ability to detect very low levels of pathological protein, applicable to various biological samples. |
| Associated Diseases | DEPRESSION, neurodegeneration, PROGRESSIVE SUPRANUCLEAR PALSY, T2DM |
| Known Drugs/Compounds | EPS |
| Interactions | ACHE, AD, AKT, ALS, AMPK, APOE |
| KG Connections | 909 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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