| Gene Symbol | RAB7A |
| Full Name | RAB7A, Member RAS Oncogene Family |
| Chromosome | 3q21 |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | RAB7A encodes a small GTPase that regulates late endosomal trafficking and lysosomal function. |
| Mechanism of Action | RAB7A inhibitors or modulators would block or enhance GTPase-mediated late endosome and lysosome trafficking, disrupting autophagy flux and lysosomal degradation pathways. This can either impair pathogenic protein clearance (in certain cancers) or restore lysosomal function (in storage disorders and neurodegeneration). |
| Druggability | High (0.75) |
| Clinical Stage | Phase III |
| Pathways | Autophagy, LIPOPHAGY, Mitophagy, Mtor, Oxidative Stress |
| UniProt ID | A0A6Q8PGE6 |
| Ensembl ID | ENSG00000175756 |
| OMIM | 602298 |
| GeneCards | RAB7A |
| Human Protein Atlas | RAB7A |
| Associated Diseases | AD, ADH, Als, Alzheimer, Alzheimer's Disease |
| Known Drugs/Compounds | Lactate, Llome, rapamycin |
| Interactions | ABCG2, Actin, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK |
| SciDEX Target | View Target Profile (5 clinical trials) |
| SciDEX Hypotheses | Mitochondrial-Lysosomal Contact Site Engineering |
| KG Connections | 885 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!