Contents

MTOR Gene

🧬 Gene Info

Gene Symbol	MTOR
Full Name	Mechanistic Target of Rapamycin
Chromosome	1p36.22
Protein Type	Serine/Threonine Kinase
Target Class	Kinase
Function	mTOR is a central kinase integrating nutritional, growth factor, and energy signals
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: APOE-Dependent Autophagy Restoration
Druggability	Low (0.32)
Clinical Stage	Phase I
Molecular Weight	~289 kDa
Amino Acids	2549 amino acids
Pathways	autophagy-lysosome pathway, lysosomal biogenesis
UniProt ID	P42345
NCBI Gene ID	2475
Ensembl ID	ENSG00000164362
OMIM	601231
GeneCards	MTOR
Human Protein Atlas	MTOR
Associated Diseases	AD, ADH, Aging, Als, Alzheimer
Known Drugs/Compounds	alpelisib, Amino Acids, Arsenic trioxide, baicalein, Baicalein, Bnt162B2
Interactions	4EBP1, 6-OHDA, ABCA1, ABCG1, ABCG2, ACAT1
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	APOE-Dependent Autophagy Restoration Chronic mTORC1-ULK1 signaling blocks autophagy ini
KG Connections	5911 knowledge graph edges
Databases	GeneCards HPA STRING

No AI portrait yet

Knowledge Graph