Contents

GABRA1 Gene

🧬 Gene Info

Gene Symbol	GABRA1
Chromosome	5q34
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Positive allosteric modulator of GABA-A receptor
Mechanism of Action	GABRA1 mediates inhibitory neurotransmission through GABA-A receptor subunit composition, modulating neuronal excitability and synaptic signaling. In neurodegeneration contexts, alterations in GABRA1 expression or function can contribute to neuronal hyperexcitability, oxidative stress, and potentially accelerated cellular damage mechanisms associated with progressive neurological disorders.
Subcellular Localization	postsynaptic sites, where it clusters at synaptic junctions through interactions with gephyrin and other scaffold protei
Druggability	High (0.90)
Clinical Stage	Approved
Molecular Weight	51 kDa
Amino Acids	456 aa
Exons	11
Pathways	GABA-A receptor / inhibitory neurotransmission
UniProt ID	P14867
GeneCards	GABRA1
Human Protein Atlas	GABRA1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	beta-sitosterol
Interactions	AMYLOID, AND, APOE, App, AQP4, C1Q
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Biorhythmic Interference via Controlled Sleep Osci
KG Connections	297 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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