| Gene Symbol | Eph Receptor B4 |
| Chromosome | 5q22.1 |
| Protein Type | Kinase |
| Target Class | Kinase |
| Function | Small molecule inhibitor of receptor tyrosine kinase activity |
| Mechanism of Action | Small molecule inhibitor of receptor tyrosine kinase activity |
| Primary Expression | the ventricular zone and cortical plate, coinciding with periods of active neurogenesis and neuronal migration |
| Druggability | Low (0.43) |
| Clinical Stage | Approved |
| Pathways | Ephrin-EphB receptor signaling |
| UniProt ID | Q541P7 |
| NCBI Gene ID | 2050 |
| Ensembl ID | ENSG00000196411 |
| OMIM | 600010 |
| Cerebral cortex | High expression in layer V pyramidal neurons, particularly in prefrontal and parietal cortices |
| Associated Diseases | AD, ALI, Als, cancer |
| Known Drugs/Compounds | Icariin |
| Interactions | ADAM17, AKT, ANGPTL4, APOE, App, COMPLEMENT |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | Ephrin-B2/EphB4 Axis Manipulation |
| KG Connections | 172 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!