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🎯 Drug Targets

Browse 16 drug targets with druggability analysis, composite scores, and clinical context

16
Targets
0
High Druggability
0.33
Avg Score
15
Target Classes
Druggability Distribution
High: 0Medium: 1Low: 1Unknown: 0
Avg druggability score: 0.296
Clinical Pipeline
Approved: 1Phase III: 0Phase II: 0Phase I: 1Preclinical: 14
Total compounds: 16 · Approved: 0
Class All Classes Enzyme (35) Signaling Protein (25) Structural Protein (17) Protein (16) Gpcr (13) Ion Channel (12) Receptor (11) Transcription Factor (11) Ligand (10) Epigenetic Regulator (8) Transporter (8) Kinase (7) Other (4) Protease (4) Chaperone (4)
Druggability Low (97) Medium (56) Undruggable (19) High (10) other (3)
Sort Score Druggability Gene A-Z Market Price
Filtered by: class=protein — 16 results
CSGA CSGA Protein Phase I
Protein Medium Druggability
Score
0.42
Drug.
0.50
Safety
0.50
Drugs
0
Hyps
1
Papers
11
Prioritized from 1 SciDEX hypotheses, including: Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cross-Seeding
CHRNA7 CHRNA7 Protein
Protein Undruggable Druggability
Score
0.39
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
15
Prioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication
OCT4 OCT4 Protein
Protein Undruggable Druggability
Score
0.36
Drug.
0.23
Safety
0.50
Drugs
1
Hyps
1
Papers
23
Prioritized from 1 SciDEX hypotheses, including: Partial Neuronal Reprogramming via Modified Yamanaka Cocktail
C4B C4B Protein
Protein Undruggable Druggability
Score
0.34
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
13
Prioritized from 1 SciDEX hypotheses, including: Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippocampal CA1 Neurons
RHOT1 RHOT1 Protein
Protein Undruggable Druggability
Score
0.34
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
8
Prioritized from 1 SciDEX hypotheses, including: Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
TFEB TFEB Protein
Protein Undruggable Druggability
Score
0.34
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
12
Prioritized from 1 SciDEX hypotheses, including: The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
PHB2 PHB2 Protein
Protein Undruggable Druggability
Score
0.34
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
9
Prioritized from 1 SciDEX hypotheses, including: Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
DNAJB6 DNAJB6 Protein
Protein Undruggable Druggability
Score
0.33
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
8
Prioritized from 1 SciDEX hypotheses, including: HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
DISEASE-CAUSING DISEASE-CAUSING Protein
Protein other Druggability
Score
0.33
Drug.
0.50
Safety
0.50
Drugs
0
Hyps
1
Papers
7
CELL-TYPE-SPECIFIC CELL-TYPE-SPECIFIC Protein
Protein other Druggability
Score
0.33
Drug.
0.50
Safety
0.50
Drugs
0
Hyps
1
Papers
12
SYNTHETIC SYNTHETIC Protein
Protein other Druggability
Score
0.33
Drug.
0.50
Safety
0.50
Drugs
0
Hyps
1
Papers
7
NURR1 NURR1 Protein
Protein Undruggable Druggability
Score
0.31
Drug.
0.23
Safety
0.50
Drugs
1
Hyps
1
Papers
7
Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR
SPTLC1 SPTLC1 Protein
Protein Undruggable Druggability
Score
0.31
Drug.
0.23
Safety
0.50
Drugs
3
Hyps
1
Papers
6
Prioritized from 1 SciDEX hypotheses, including: APOE-Mediated Synaptic Lipid Raft Stabilization
TDC TDC Protein Approved
Protein Low Druggability
Score
0.30
Drug.
0.26
Safety
0.50
Drugs
1
Hyps
1
Papers
6
Prioritized from 1 SciDEX hypotheses, including: Restoring Neuroprotective Tryptophan Metabolism via Targeted Probiotic Engineering
AGER AGER Protein
Protein Undruggable Druggability
Score
0.30
Drug.
0.23
Safety
0.50
Drugs
10
Hyps
1
Papers
7
Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade
PGC1A PGC1A Protein
Protein Undruggable Druggability
Score
0.28
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
7
Prioritized from 1 SciDEX hypotheses, including: Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits
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