PGC1A

PGC1A Protein

Score: 0.277 Price: $0.28 Undruggable Druggability Status: active Wiki: PGC1A Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 PGC1A — PDB 5WJY Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits

Known Drugs:

No known drugs targeting this protein

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: Q9UBK2

🧬 3D Protein Structure

🧬 PGC1A — PDB 5WJY Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for Q9UBK2

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Linked Hypotheses (0)

No linked hypotheses

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

activates (14)

PGC1A→NRF1PGC1A→NRF2PGC1A→MITOCHONDRIAL_BIOGENESISPGC1A→OXIDATIVE_PHOSPHORYLATIONPGC1A→ATP_PRODUCTION

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PGC1A→CELL_MIGRATIONPGC1A→STAT3FASN→PGC1ANFKBIA→PGC1APGC1A→LPLPGC1A→CLOCKPGC1A→SIRT1PGC1A→PPARGPGC1A→NLRP3

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