TDC

TDC Protein

Score: 0.304 Price: $0.30 Low Druggability Status: active

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🔮 TDC — AlphaFold P20711 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Druggability & Clinical Context

Druggability

Low

Score: 0.26

Clinical Stage

Approved

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.60

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (1 compounds)

1 Preclinical

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Restoring Neuroprotective Tryptophan Metabolism via Targeted Probiotic Engineering

Drug Pipeline (1 compounds)

1 Preclinical

Known Drugs:

CHEMBL3228258 (preclinical)

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: P20711

🔮 Predicted Protein Structure (AlphaFold)

🔮 TDC — AlphaFold P20711 Click to expand interactive 3D viewer

AI-predicted structure from AlphaFold EBI | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for P20711

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Clinical Trials (3)

Relevant trials from ClinicalTrials.gov

Active

Completed

Total Enrollment

184

By Phase

PHASE2: 1 · PHASE4: 2

OpicApone Sleep dISorder Completed

PHASE4 NCT04986995 n=22

Parkinson Disease

Interventions: Opicapone

Sponsor: Bial - Portela C S.A. | Started: 2021-06-09

OpiCapone Effect on Motor Fluctuations and pAiN Completed

PHASE4 NCT04986982 n=144

Parkinson Disease

Interventions: Opicapone 50 mg, Placebo

Sponsor: Bial - Portela C S.A. | Started: 2021-02-25

Mucuna Pruriens Therapy in Parkinson's Disease Completed

PHASE2 NCT02680977 n=18

Parkinson's Disease

Interventions: MP-Equivalent, MP-Low, MP+DDCI

Sponsor: ASST Gaetano Pini-CTO | Started: 2016-02

Linked Hypotheses (1)

Restoring Neuroprotective Tryptophan Metabolism via Targeted Probiotic Engineering0.612

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

▸ Show 2 more

TDC→AGERTDC→CSGA

co mentioned (2)

neuroinflammation→TDCAADC→TDC

debate co mention (5)

CSGA→TDCGPR109A→TDCneuroinflammation→TDCTDC→TLR4DDC→TDC

participates in (1)

TDC→insulin signaling

Debate History (1)

Should TDC (TDC Protein) be prioritized as a therapeutic target for neurodegener2026-04-26

TDC