SPTLC1

SPTLC1 Protein

Score: 0.307 Price: $0.31 Undruggable Druggability Status: active Wiki: SPTLC1 - Serine Palmitoyltransferase

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 SPTLC1 — PDB 4HWL Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (3 compounds)

3 Preclinical

Mechanism: Prioritized from 1 SciDEX hypotheses, including: APOE-Mediated Synaptic Lipid Raft Stabilization

Drug Pipeline (3 compounds)

3 Preclinical

Known Drugs:

CHEMBL1241090 (preclinical)

CHEMBL4584997 (preclinical)

CHEMBL4541898 (preclinical)

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: O15269

🧬 3D Protein Structure

🧬 SPTLC1 — PDB 4HWL Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for O15269

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Linked Hypotheses (1)

APOE-Mediated Synaptic Lipid Raft Stabilization0.649

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

▸ Show 2 more

SPTLC1→HSPA1ASPTLC1→APOE

expressed in (2)

SPTLC2→SPTLC1SPTLC1→KCNJ6

interacts with (1)

SPTLC1→ORMDL proteins

involved in (3)

SPTLC1→Sphingolipid biosynthesisSPTLC1→1-DeoxysphingolipidsSerine palmitoyltransferase→SPTLC1

regulates (1)

SPTLC1→Sphingolipid metabolism

therapeutic target (1)

CERS2→SPTLC1

Debate History (0)

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