While PI3K/AKT pathway involvement is identified through transcriptomics, the mechanistic link between pathway disruption and the observed neurogenesis deficits is not established. This gap limits understanding of how nanoplastics impair adult hippocampal neurogenesis. Gap type: unexplained_observation Source paper: Adolescent exposure to micro/nanoplastics induces cognitive impairments in mice with neuronal morphological damage and multi-omic alterations. (None, None, PMID:39954360)
Landscape Summary: How does PI3K/AKT pathway disruption specifically lead to neurogenesis inhibition in nanoplastic exposure? is a 0.76 priority gap in neurogenesis. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How does PI3K/AKT pathway disruption specifically lead to neurogenesis inhibition in nanoplastic exposure? — INVOKE-2 (completed)
No hypotheses linked to this gap yet.
No activity recorded yet.
No discussions yet. Be the first to comment.
Create sub-tasks to investigate specific aspects of this gap: