Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRPM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| tumor cell proliferation | regulates | process | 0.85 |
| cancer | biomarker_for | disease | 0.82 |
| tumor cell invasion | promotes | process | 0.80 |
| PI3K/AKT | activates | pathway | 0.80 |
| MAPK | activates | pathway | 0.80 |
| autophagy | regulates | process | 0.78 |
| Wnt/β-catenin | modulates | pathway | 0.75 |
| P53 | modulates | pathway | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Spatiotemporal coupling between TRPML1-mediated lysosomal ca | 0.705 | neurodegeneration | What determines the specificity of calci |
| PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5 | 0.584 | neurodegeneration | How does PIKFYVE inhibition activate unc |
| Sequential TRPML1 Activation Following Autophagy Priming | 0.575 | neurodegeneration | Does TRPML1 enhancement cause therapeuti |
| TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosoma | 0.560 | neurodegeneration | Does TRPML1 enhancement cause therapeuti |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.575
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PPP3/calcineurin-dependent TFEB dephosphorylation mechanism | exploratory | motoneuron degeneration | 0.800 | 0.00 | neuronal cell lines | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-21
closed · Rounds: 4 · Score: 0.46 · 2026-04-16
Hypotheses and analyses mentioning TRPM in their description or question text
No additional research found