| Gene Symbol | TRPM4 |
| Aliases | Transient Receptor Potential Cation Channel Subfamily M Member 4 |
| Protein Type | Channel |
| Function | Calcium activation — Intracellular Ca²⁺ directly activates TRPM4, with activation threshold around 1-10 μM |
| Primary Expression | numerous tissues including the heart, immune system, and brain |
| Molecular Weight | 134 kDa |
| Ensembl ID | ENSG00000130589 |
| GeneCards | TRPM4 |
| Human Protein Atlas | TRPM4 |
| Intracellular calcium | Primary activator |
| Voltage | Depolarization increases open probability |
| Phosphorylation | PKC and CaM kinase II can modulate activity |
| ATP | Intracellular ATP can inhibit the channel |
| pH | Intracellular pH affects channel function |
| Calmodulin | Mediates Ca²⁺-dependent activation |
| Associated Diseases | Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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