gene 1,940 words KG: THBS4
Contents

THBS4 Gene

🧬 Gene Info
Gene SymbolTHBS4
Full NameThrombospondin 4
Chromosome5q13.2
Functionis a secreted protein that
Primary Expressionthe nervous system and plays unique roles in neural circuit formation and maintenance [@born2017]
Molecular Weight110 kDa
Amino Acids870 aa
Exons22
PathwaysWnt
UniProt ID[P35443](https://www.uniprot.org/uniprot/P35443)
Ensembl IDENSG00000113205
GeneCardsTHBS4
Human Protein AtlasTHBS4
Chromosomal location5q13.2
Genomic size~16 kb
Associated Diseasesneurodegeneration
InteractionsCytokine, CYTOKINES, Egfr, EGFR, MYC, P53
KG Connections18 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
CYP46A1 Overexpression Gene Therapy
Score: 0.95
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Blood-Brain Barrier SPM Shuttle System
Score: 0.53

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Neurodegeneration
disease · KG edge: implicated_in
TNF (Redirect)
redirect · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates
MYC Gene
gene · KG edge: activates
SMAD3 — SMAD Family Member 3
gene · KG edge: activates

Knowledge Graph (12 edges)

SMAD3 activates THBS4
MYC activates THBS4
LOX encodes THBS4
THBS4 activates TNF
THBS4 activates TGFB1
THBS4 activates EGFR
P53 activates THBS4
THBS4 activates CYTOKINES
THBS4 activates Diabetes
THBS4 activates Fibrosis

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