concept

TAU AGGREGATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU AGGREGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

1Hypotheses

3Analyses

14Outgoing

36Incoming

0Experiments

3Debates

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💡 Concept Info

Name	TAU AGGREGATION

Pathway Diagram

graph TD
    TAU_AGGREGATION["TAU AGGREGATION"]
    TAU_AGGREGATION -->|"causes"| Alzheimer_s_Disease["Alzheimer's Disease"]
    TAU_AGGREGATION -->|"causes"| Tauopathies["Tauopathies"]
    TAU_AGGREGATION -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    MAPT["MAPT"] -->|"involved_in"| TAU_AGGREGATION
    TRIM11["TRIM11"] -->|"inhibits"| TAU_AGGREGATION
    TAU["TAU"] -->|"implicated in"| TAU_AGGREGATION
    Misfolded_Tau["Misfolded Tau"] -->|"causes"| TAU_AGGREGATION
    Neddylation_Inhibition["Neddylation Inhibition"] -->|"upregulates"| TAU_AGGREGATION
    AQP4["AQP4"] -.protects against.-> TAU_AGGREGATION
    Impaired_Glymphatic_Clearance["Impaired Glymphatic Clearance"] -->|"contributes to"| TAU_AGGREGATION
    BMAL1["BMAL1"] -->|"regulates"| TAU_AGGREGATION

Outgoing (14)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer's Disease	causes	disease	0.95
Tauopathies	causes	disease	0.95
Neurodegeneration	causes	disease	0.95
neurodegeneration	mediates	process	0.93
neuronal dysfunction	promotes	phenotype	0.92
Alzheimer's Disease	biomarker_for	disease	0.92
Frontotemporal Dementia	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
tau seeds	propagates	protein_aggregate	0.90
cognitive decline	drives	phenotype	0.88
Neurodegeneration	contributes_to	process	0.88
tau propagation	promotes	process	0.70
cellular senescence	causes (tau aggregation triggers cellular senescence respo)	mechanism	0.70

Incoming (36)

Source	Relation	Type	Str
MAPT	involved_in	protein	0.95
AMYLOID-BETA	associated_with	protein	0.95
TRIM11	inhibits	protein	0.95
TAU	implicated_in	entity	0.92
Neddylation Inhibition	upregulates	mechanism	0.90
AQP4	protects_against	gene	0.90
Impaired Glymphatic Clearance	contributes_to	process	0.90
BMAL1	promotes	gene	0.90
TAU	involved_in	protein	0.90
CDK5	mediates	protein	0.90
TAU	propagates	protein	0.90
41478829	reduces	paper	0.90
BMAL1	regulates	gene	0.90
28678775	defines the seed for	paper	0.90
Misfolded Tau	causes	protein	0.90
36563857	prevented	paper	0.90
Tau Hyperphosphorylation	contributes_to	process	0.85
Prion-like Propagation	mediates	mechanism	0.85
Tau Phosphorylation	associated_with	process	0.85
BMAL1	inhibits	gene	0.85
Heparin	associated_with	drug	0.85
Protopanaxatriol	inhibits	compound	0.85
Tau Mutations	contributes_to	mechanism	0.85
Tau mRNA Splicing Disruption	contributes_to	process	0.85
Tau Post-Translational Modifications	contributes_to	process	0.85
Inflammation	contributes_to	process	0.80
Oxidative Stress	contributes_to	process	0.80
GPCR dysregulation	promotes	phenotype	0.80
autophagy	protects_against	process	0.70
p62	regulates	protein	0.70
Amyloid-β	activates	protein	0.70
cellular senescence	causes (senescence creates a self-perpetuating cycle by pr)	mechanism	0.70
O-GlcNAcylation Thr231	inhibits	protein	0.70
AQP4 inhibition	promotes	process	0.70
30232451	modulates	paper	0.60
HSPG2	regulates	protein	0.60