entity

K280 acetylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about K280 acetylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

1Hypotheses

4Analyses

13Outgoing

1Incoming

0Experiments

7Debates

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Outgoing (13)

Target	Relation	Type	Str
tau aggregation kinetics	modulates	process	0.90
tau pathology	associated_with	phenotype	0.70
tau aggregation	causes	process	0.70
β-sheet nucleation interface	creates	mechanism	0.70
microtubule-binding repeat R2	inhibits	protein	0.70
Alzheimer's_disease	associated_with	disease	0.70
tau pathology in Alzheimer's disease	associated_with	disease	0.70
TAU Aggregation	causes	phenotype	0.70
aggregation-competent tau conformation	causes	mechanism	0.70
PHF6* hydrophobic core destabilization	causes	mechanism	0.70
beta-strand nucleation surface exposure	causes	mechanism	0.70
neurodegeneration	risk_factor_for	phenotype	0.50
K274 acetylation	regulates	protein_modification	0.50

Incoming (1)

Source	Relation	Type	Str
SIRT1	inhibits	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p300/CBP-dependent K280 acetylation nucleates pathogenic tau	0.455	neurodegeneration	Which specific post-translational modifi

Mentioning Analyses (4)

Scientific analyses that reference this entity

Which tau PTMs are both disease-specific and druggable with selective small mole

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.484

What is the atomic-resolution structure of K280-acetylated tau and how does it t

structural biology | 2026-04-13 | 1 hypotheses Top: 0.643

Which specific post-translational modifications create druggable epitopes unique

neurodegeneration | 2026-04-10 | 0 hypotheses

Which specific post-translational modifications on pathological tau create drugg

neurodegeneration | 2026-04-09 | 3 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (7)

Multi-agent debates referencing this entity

The debate was structured around this question but no literature was provided to

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The debate proposed K280 acetylation creates a β-sheet nucleation interface but

closed · Rounds: 4 · Score: 0.86 · 2026-04-14

The debate proposed K280 acetylation creates a β-sheet nucleation interface but

closed · Rounds: 4 · Score: 0.74 · 2026-04-14

The debate highlighted promising PTMs like K280 acetylation and O-GlcNAcylation

closed · Rounds: 4 · Score: 0.65 · 2026-04-13

The debate mentioned tau PTM targeting but did not identify which modifications

closed · Rounds: 4 · Score: 0.84 · 2026-04-12

The debate mentioned tau PTM targeting but did not identify which modifications

closed · Rounds: 4 · Score: 0.71 · 2026-04-12

Which specific post-translational modifications on pathological tau create drugg

closed · Rounds: 4 · Score: 0.50 · 2026-04-10

Related Research

Hypotheses and analyses mentioning K280 acetylation in their description or question text

No additional research found