gene

TRIM11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

29Outgoing

7Incoming

0Experiments

0Debates

Summary

TRIM11 (Tripartite Motif Containing 11) — brain-expressed E3 ubiquitin ligase regulating protein quality control, amyloid clearance, and neuronal survival in Alzheimer's disease and prion disease

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TRIM11
Aliases	Tripartite Motif Containing 11
Chromosome	1q42.13
Protein Type	Gene
Function	encodes a protein of approximately 462 amino acids with a molecular weight of approximately 52 kDa.
Primary Expression	the brain, with high expression in the cerebral cortex, hippocampus, [cerebellum](/brain-region
Molecular Weight	52 kDa
Amino Acids	462 aa
Pathways	Proteasomal Degradation
GeneCards	TRIM11
Human Protein Atlas	TRIM11
Associated Diseases	Inflammation, Neuron Viability, Tau Solubility
KG Connections	36 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TRIM11 Gene

gene · 1610 words

→

Pathway Diagram

graph TD
    TRIM11["TRIM11"]
    Tau_Aggregation["Tau Aggregation"]
    TRIM11 -.->|"inhibits"| Tau_Aggregation
    Alzheimer_s_Disease{"Alzheimer's Disease"}
    TRIM11 -.->|"downregulates"| Alzheimer_s_Disease
    TAU(["TAU"])
    TRIM11 -->|"degrades"| TAU
    Tauopathies{"Tauopathies"}
    TRIM11 -->|"protects_against"| Tauopathies
    Proteasomal_Degradation["Proteasomal Degradation"]
    TRIM11 -->|"involved_in"| Proteasomal_Degradation
    Tau_Solubility["Tau Solubility"]
    TRIM11 -->|"associated_with"| Tau_Solubility
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"treats"| TRIM11
    style TRIM11 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (29)

Target	Relation	Type	Str
Tau Aggregation	inhibits	process	0.95
Alzheimer's Disease	downregulates	disease	0.95
Tauopathies	protects_against	disease	0.90
Proteasomal Degradation	involved_in	process	0.90
Tau Solubility	associated_with	phenotype	0.90
TAU	degrades	protein	0.90
Neuron Viability	associated_with	phenotype	0.85
Tau Fibrils	associated_with	process	0.85
Tau Misfolding	inhibits	process	0.85
Cognitive Impairment	modulates	phenotype	0.85
Neuroinflammation	associated_with	process	0.85
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
AND	regulates	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Neuron	associated_with	cell_type	0.60
Actin	regulates	protein	0.60
neurons	expressed_in	cell_type	0.60
TAU	regulates	gene	0.60
neuroinflammation	interacts_with	disease	0.60
Neuron	expressed_in	cell_type	0.55
ALZHEIMER'S	regulates	concept	0.50
NEURONS	associated_with	concept	0.50
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
disease	regulates	disease	0.50

Incoming (7)

Source	Relation	Type	Str
TAU	activates	entity	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
TAU	regulates	gene	0.60
NEUROINFLAMMATION	treats	entity	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
Neuroinflammation	inhibits	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRIM11 in their description or question text

No additional research found