concept

SYNAPTIC PLASTICITY GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC PLASTICITY GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

1Hypotheses

1Analyses

19Outgoing

23Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	SYNAPTIC PLASTICITY GENES

Pathway Diagram

graph TD
    SYNAPTIC_PLASTICITY_GENES["SYNAPTIC PLASTICITY GENES"]
    SYNAPTIC_PLASTICITY_GENES -->|"studied_in"| neurodegeneration["neurodegeneration"]
    SYNAPTIC_PLASTICITY_GENES -->|"interacts"| BDNF["BDNF"]
    SYNAPTIC_PLASTICITY_GENES -->|"interacts"| CREB1["CREB1"]
    BDNF -->|"interacts"| SYNAPTIC_PLASTICITY_GENES
    CREB1 -->|"interacts"| SYNAPTIC_PLASTICITY_GENES
    Longevity_and_Rejuvenation_The["Longevity and Rejuvenation Therapies Landscape"] -->|"references"| SYNAPTIC_PLASTICITY_GENES
    Epigenetic_Therapies_for_Neuro["Epigenetic Therapies for Neurodegeneration"] -->|"references"| SYNAPTIC_PLASTICITY_GENES
    SPAM1__SIRT6_Positive_Alloster["SPAM1: SIRT6 Positive Allosteric Modulator"] -->|"references"| SYNAPTIC_PLASTICITY_GENES
    Epigenetic_Editing_and_CRISPR_["Epigenetic Editing and CRISPR Approaches in CBS/PSP"] -->|"references"| SYNAPTIC_PLASTICITY_GENES
    Section_192_Advanced_Epigenomi["Section 192 Advanced Epigenomics and Chromatin Therapy in CBS/PSP"] -->|"references"| SYNAPTIC_PLASTICITY_GENES
    ONO_2020_for_Alzheimer_s_Disea["ONO-2020 for Alzheimer's Disease (NCT06881836)"] -->|"references"| SYNAPTIC_PLASTICITY_GENES

Outgoing (19)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SYNAPTIC PLASTICITY GENES	data_in	dataset_row	0.00
CREB1	interacts_with	gene	0.48
neurodegeneration	associated_with	disease	0.48
BDNF	interacts_with	gene	0.48
Disease-causing mutations with integrated reporters	co_discussed	gene	0.40
NURR1	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
HMGCR	co_discussed	gene	0.40
mitochondrial biogenesis genes	co_discussed	gene	0.40
HTT	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
APOE regulatory regions	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40
Cell-type-specific essential genes	co_discussed	gene	0.40
APOE	co_discussed	gene	0.40
PITX3	co_discussed	gene	0.40
neuronal identity transcription factors	co_discussed	gene	0.40

Incoming (23)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SYNAPTIC PLASTICITY GENES	data_in	dataset_row	0.00
h-29ef94d5	targets_gene	hypothesis	0.90
BDNF	interacts_with	gene	0.48
CREB1	interacts_with	gene	0.48
ONO-2020 for Alzheimer's Disease (NCT06881836)	references	clinical	0.40
CREB1	co_discussed	gene	0.40
NRSF Protein	references	protein	0.40
HDAC4 Protein	references	protein	0.40
MAX Protein (MAX)	references	protein	0.40
Cell-type-specific essential genes	co_discussed	gene	0.40
APOE regulatory regions	co_discussed	gene	0.40
NURR1	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40
PGC1A	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
HTT	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
APOE	co_discussed	gene	0.40
repeat-containing transcripts	co_discussed	gene	0.40
PITX3	co_discussed	gene	0.40
DMPK	co_discussed	gene	0.40
neuronal identity transcription factors	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes	0.530	neurodegeneration	Comparative epigenetic signatures: DNA m

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.827

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning SYNAPTIC PLASTICITY GENES in their description or question text

No additional research found