entity

RIC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

30Hypotheses

0Analyses

11Outgoing

2Incoming

14Experiments

0Debates

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Wiki Pages (6)

Knowledge base pages for this entity

Outgoing (11)

Target	Relation	Type	Str
Inflammation	associated_with	process	0.95
Oxidative Stress	associated_with	process	0.95
NFE2L2	upregulates	protein	0.92
HO1	upregulates	protein	0.92
IL1B	downregulates	protein	0.90
IL6	downregulates	protein	0.90
TNF	downregulates	protein	0.90
NLRP3	downregulates	protein	0.90
KEAP1	downregulates	protein	0.90
oxidative stress	attenuates	process	0.80
INFLAMMATION	attenuates	process	0.80

Incoming (2)

Source	Relation	Type	Str
34185099	decreased	paper	0.90
34185099	protected	paper	0.90

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4 Allosteric Rescue via Small Molecule Chaperones	0.765	neurodegeneration	APOE4 structural biology and therapeutic
Circulating Soluble PDGFRβ Reflects Pericyte Loss and Preced	0.745	-	What blood-brain barrier permeability ch
Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002	0.733	molecular neurobiology	View
APOE4-driven pericyte injury/senescence is an upstream drive	0.720	neurodegeneration	Does pericyte senescence drive BBB break
Bacterial Curli Amyloid → Nucleation of α-Synuclein Misfoldi	0.720	neurodegeneration	What are the mechanisms by which gut mic

Soluble PDGFRβ as a Peripheral Indicator of Pericyte-Mediate	0.705	-	What blood-brain barrier permeability ch
Pericyte-targeted senolysis or senomorphic therapy will bene	0.700	neurodegeneration	Does pericyte senescence drive BBB break
Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.684	neurodegeneration	Perivascular spaces and glymphatic clear
Bacterial Tyramine–Induced DOPAL Accumulation in Enteric Neu	0.680	neurodegeneration	What are the mechanisms by which gut mic
Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-	0.662	-	Blood-brain barrier permeability changes
Radiation drives pericyte senescence through lysosome acidif	0.652	neurodegeneration	What specific autophagy pathways are def
Mitochondrial ATP/ADP Carrier Activity as Bioenergetic Recov	0.642	translational neuroscience	Which metabolic biomarkers can distingui
Glycine-Rich Domain Competitive Inhibition	0.640	neurodegeneration	TDP-43 phase separation therapeutics for
Amyloid-beta induces secondary pericyte senescence after con	0.640	neurodegeneration	Does pericyte senescence drive BBB break
Caloric Restriction Mimetic Combination Therapy (Metformin +	0.640	neurodegeneration	-
Enteric Nervous System Dysfunction as Self-Reinforcing Patho	0.630	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M
Pericyte senescence is sufficient to weaken the BBB even wit	0.630	neurodegeneration	Does pericyte senescence drive BBB break
Steric Occlusion of G3BP1 Oligomerization Interface	0.630	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
APOE4-microglial complement signaling causes cholinergic-enr	0.630	neurodegeneration	What determines the temporal sequence of
Circulating Soluble PDGFRβ Reflects Pericyte Loss and Preced	0.625	-	What blood-brain barrier permeability ch
Serine/Arginine-Rich Protein Kinase Modulation	0.624	neurodegeneration	TDP-43 phase separation therapeutics for
H7: Enteric Nervous System Alpha-Synuclein Propagation Block	0.620	neurodegeneration	How does engineered C. butyricum cross t
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.613	neurodegeneration	What are the mechanisms by which gut mic
CSF ApoE- and clusterin-rich lipoprotein particles stabilize	0.606	neurodegeneration	Which specific CSF molecular components
whether the Mitochondrial transfer between neurons and glia	0.604	neurodegeneration	Methodology challenge: notebook 'Mitocho
whether the Astrocyte reactivity subtypes in neurodegenerati	0.604	neurodegeneration	Methodology challenge: notebook 'Astrocy
whether the Mitochondrial transfer between neurons and glia	0.604	neurodegeneration	Methodology challenge: notebook 'Mitocho
Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Pr	0.600	-	What blood-brain barrier permeability ch
Stratified falsifiers should govern Methodology challenge: n	0.591	neurodegeneration	Methodology challenge: notebook 'Astrocy
Stratified falsifiers should govern Methodology challenge: n	0.591	neurodegeneration	Methodology challenge: notebook 'Mitocho

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (14)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
GWAS of plasma NfL in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma pTau217 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
Dairy intake and dementia risk in Malmö Diet and Cancer cohort	clinical	Alzheimer's disease	0.950	0.00	Swedish community-based adults	proposed	N/A
GWAS of plasma pTau181 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma GFAP in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
KEEPS Continuation: Long-term effects of menopausal hormone therapy on	clinical	Alzheimer's disease	0.950	0.00	recently menopausal women with	proposed	N/A
GWAS of composite biomarker score	exploratory	Alzheimer's disease	0.900	0.00	human patients - East Asian co	proposed	N/A
RBG treatment in ApoE-/- atherosclerosis mouse model	validation	atherosclerosis	0.900	0.00	ApoE-/- mice	proposed	N/A
Irisin effects on angiogenesis in human endothelial cells	exploratory	bone fracture	0.900	0.00	human umbilical vein endotheli	proposed	N/A
APOE4 association with TDP-43 pathology in AD	exploratory	Alzheimer's disease	0.750	0.00	human patients	proposed	N/A
s:** - Biochemical binding assays measuring PROTAC selectivity for APO	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591]	Rusmini P, Cortese K, Crippa V, Cristofa	Autophagy	2019	2
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726]	Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu	Cell Stem Cell	2025	1
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685]	Litvinchuk A, Suh JH, Guo JL, Lin K, Dav	Neuron	2024	1
The cell biology of APOE in the brain. [PMID:37805344]	Windham IA, Cohen S	Trends Cell Biol	2024	1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043]	Kempuraj D, Dourvetakis KD, Cohen J, Val	Front Cell Neurosci	2024	1
The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066]	Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T	Int J Mol Sci	2023	1
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317]	Maxine R Nelson, Peng Liu, Ayushi Agrawa	Nature neuroscience	2023	1
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333]	Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z	Nature	2021	1
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954]	Montagne A, Nation DA, Sagare AP, Barisa	Nature	2020	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188]	Cetindag AC, Schipke CG, Esselmann H, Kr	The journal of prevention of A	2026	0
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026	0
ASS1 Promotes Atherosclerotic Inflammation Through the NLRP3/IL-33/ST2 Axis in O [PMID:41914296]	Wu S, Han F, Qiao Z, Yuan S, Bian X, Zha	Frontiers in bioscience (Landm	2026	0
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033]	Levey J, Howe M, Douglas K, Odame E, Raj	bioRxiv : the preprint server	2026	0
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635]	Thedim M, Hu J, Maher M, Wiener-Kronish	Br J Anaesth	2026	0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639]	Bae H, Song Z, Ali A, Sasaki T, Tesi N e	Geroscience	2026	0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401]	Stern A, Linial M	Geroscience	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RIC in their description or question text

Soluble PDGFRβ as a Peripheral Indicator of Pericyte-Mediated Blood-Brain Barrie

Score: 0.705 · unknown disease · 2026-04-26

Pericyte loss in Alzheimer's disease leads to proteolytic shedding of PDGFRβ into circulation, providing a blood-accessi

Pericyte-targeted senolysis or senomorphic therapy will benefit only an early bi

Score: 0.700 · neurodegeneration · 2026-04-25

Therapeutic benefit from pericyte-directed senescence interventions depends on stage. If BBB leak and dysfunction occur

Pericyte Contractility Reset via Selective PDGFR-β Agonism

Score: 0.684 · neurodegeneration · 2026-04-02

## Mechanistic Overview Pericyte Contractility Reset via Selective PDGFR-β Agonism starts from the claim that modulating

Bacterial Tyramine–Induced DOPAL Accumulation in Enteric Neurons

Score: 0.680 · neurodegeneration · 2026-04-22

## **Molecular Mechanism and Rationale** The proposed mechanism centers on a complex interplay between gut microbiota,

Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-β as Sentinel Event

Score: 0.662 · unknown disease · 2026-04-26

CSF soluble PDGFR-β shedding from pericytes as the earliest detectable molecular event in AD, preceding amyloid/tau path

Radiation drives pericyte senescence through lysosome acidification failure and

Score: 0.652 · neurodegeneration · 2026-04-25

Autophagosomes still form after irradiation, but damaged lysosomes cannot clear cargo, sustaining ROS and SASP output.

Mitochondrial ATP/ADP Carrier Activity as Bioenergetic Recovery Metric

Score: 0.642 · translational neuroscience · 2026-04-16

## **Molecular Mechanism and Rationale** The adenine nucleotide translocator (ANT), encoded by the SLC25A4 gene and als

Glycine-Rich Domain Competitive Inhibition

Score: 0.640 · neurodegeneration · 2026-04-02

## Mechanistic Overview Glycine-Rich Domain Competitive Inhibition starts from the claim that modulating TARDBP within t

Amyloid-beta induces secondary pericyte senescence after contractile and oxidati

Score: 0.640 · neurodegeneration · 2026-04-25

Soluble Aβ oligomers trigger endothelin-1 and ROS-dependent pericyte contractile stress, and repeated exposure converts

Enteric Nervous System Dysfunction as Self-Reinforcing Pathological Loop

Score: 0.630 · neurodegeneration · 2026-04-26

PD patients exhibit dual ENS pathology: α-synuclein aggregation within enteric neurons and progressive loss of cholinerg

Pericyte senescence is sufficient to weaken the BBB even without classic amyloid

Score: 0.630 · neurodegeneration · 2026-04-25

Selective induction of a senescence program in adult pericytes is sufficient to impair barrier-supportive trophic signal

Steric Occlusion of G3BP1 Oligomerization Interface

Score: 0.630 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The hypothesis centers on the precise regulation of G3BP1 (Ras GTPase-activating

APOE4-microglial complement signaling causes cholinergic-enriched synaptic vulne