| Gene Symbol | RIC3 |
| Aliases | RIC3PROTEIN |
| Chromosome | 7p14.3 |
| Protein Type | Gene |
| Function | RIC3 (Resistant to Inhibitors of Cholinesterase 3) is a transmembrane chaperone protein that plays a critical role in the assembly and trafficking of nicotinic acetylcholine receptors (nAChRs). |
| Primary Expression | neurons and supports synaptic cholinergic signaling |
| Amino Acids | 461 aa |
| UniProt ID | Q86XR7 |
| GeneCards | RIC3 |
| Human Protein Atlas | RIC3 |
| N-terminal ER Signal Sequence | Targets RIC3 to the ER |
| Transmembrane Domain | Single transmembrane helix anchors RIC3 in the ER membrane |
| Large Luminal Loop | The functional domain facing the ER lumen |
| C-terminal Cytoplasmic Tail | Small cytoplasmic domain |
| Coiled-coil Domains | Mediate subunit interactions |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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