Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RPL5 |
| Full Name | Ribosomal Protein L5 |
| Chromosome | 1p22.1 |
| Function | RPL5 is a ribosomal protein component of the 60S large ribosomal subunit. |
| Amino Acids | 297 aa |
| Pathways | ubiquitin-proteasome |
| UniProt ID | P46777 |
| NCBI Gene ID | 6125 |
| Ensembl ID | ENSG00000122406 |
| OMIM | 603634 |
| GeneCards | RPL5 |
| Human Protein Atlas | RPL5 |
| Protein synthesis | As part of the 60S subunit, RPL5 participates in the peptidyl transferase activity during protein translation |
| Ribosome assembly | RPL5 is essential for the proper assembly and maturation of the 60S ribosomal subunit |
| MDM2-p53 interaction | RPL5 binds to MDM2 and inhibits MDM2-mediated p53 ubiquitination, thereby stabilizing p53 and activating tumor suppressor pathways |
| Associated Diseases | neurodegeneration |
| Interactions | MDM2, NPM1, RPL11 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RPL5["RPL5"]
style RPL5 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
ubiquitin_proteasome(("ubiquitin-proteasome"))
NPM1["NPM1"]
MDM2["MDM2"]
RPL11["RPL11"]
neurodegeneration["neurodegeneration"]
RPL5 -->|"participates_in"| ubiquitin_proteasome
NPM1 -->|"activates"| RPL5
MDM2 -->|"activates"| RPL5
RPL11 -->|"activates"| RPL5
RPL5 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class ubiquitin_proteasome pathway
class NPM1 gene
class MDM2 gene
class RPL11 gene
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| ubiquitin-proteasome | participates_in | pathway | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RPL5 in their description or question text
No additional research found