gene

PSMA5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

2Outgoing

5Incoming

0Experiments

0Debates

Summary

PSMA5 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PSMA5
Full Name	Proteasome Subunit Alpha 5
Chromosome	1p13.3
Function	This ring serves as the gatekeeper for the proteolytic chamber, controlling access of substrates to the catalytic beta subunits.
UniProt ID	P28066
NCBI Gene ID	5686
Ensembl ID	ENSG00000143106
OMIM	176845
GeneCards	PSMA5
Human Protein Atlas	PSMA5
Associated Diseases	neurodegeneration
Interactions	APP, PSMB7
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PSMA5 — AlphaFold P28066 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PSMA5 Gene

gene · 751 words

→

PSMA5 Protein

protein · 847 words

→

Pathway Diagram

graph TD
    PSMA5["PSMA5"]
    Alzheimer{"Alzheimer"}
    PSMA5 -->|"expressed in"| Alzheimer
    Neurogenesis(["Neurogenesis"])
    PSMA5 -->|"expressed in"| Neurogenesis
    neurodegeneration["neurodegeneration"]
    PSMA5 -->|"implicated in"| neurodegeneration
    PSMB7["PSMB7"]
    PSMB7 -->|"inhibits"| PSMA5
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed in"| PSMA5
    P53["P53"]
    P53 -->|"expressed in"| PSMA5
    APP["APP"]
    APP -->|"inhibits"| PSMA5
    style PSMA5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (2)

Target	Relation	Type	Str
Alzheimer	expressed_in	disease	0.65
Neurogenesis	expressed_in	pathway	0.60

Incoming (5)

Source	Relation	Type	Str
APP	downregulates	protein	0.70
PSMB7	inhibits	gene	0.60
APP	inhibits	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
P53	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSMA5 in their description or question text

No additional research found