protein

PP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

23Hypotheses

4Analyses

1Outgoing

1Incoming

4Experiments

4Debates

Summary

Page for PP1 Protein

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🔬 Protein Info

Gene Symbol	PP1
Function	Pp1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Molecular Weight	37 kDa
GeneCards	PP1
Human Protein Atlas	PP1
Associated Diseases	ALS
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    N0["PP1"]
    N1["PPP1R7"]
    N1 -->|"component of"| N0
    N2["ALS"]
    N0 -->|"associated with"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 disease

Outgoing (1)

Target	Relation	Type	Str
ALS	associated_with	disease	0.60

Incoming (1)

Source	Relation	Type	Str
PPP1R7	component_of	gene	0.80

Targeting Hypotheses (23)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects S	0.753	synaptic biology	Does SPP1-mediated synaptic engulfment r
Temporal SPP1 Inhibition During Critical Windows	0.752	neuroinflammation	What molecular mechanisms mediate SPP1-i
SPP1+ DAM as Source of Autoimmunity in Neurodegeneration	0.660	Alzheimer's disease	-
Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift	0.620	neuroinflammation	What molecular mechanisms mediate SPP1-i
PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In	0.618	neurodegeneration	How do perivascular cells specifically r

Complement Cascade Specificity: Microglial C3aR Antagonism D	0.618	synaptic biology	Does SPP1-mediated synaptic engulfment r
LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasom	0.617	neurodegeneration	How do perivascular cells specifically r
Temporal NLRP3 Inhibition During SPP1-Driven Microglial Acti	0.551	neuroinflammation	What molecular mechanisms mediate SPP1-i
Astrocytic SPP1 Modulation Through STAT3-Dependent Transcrip	0.551	neuroinflammation	What molecular mechanisms mediate SPP1-i
Synaptic Vulnerability Window Temporal Targeting: Transient	0.536	synaptic biology	Does SPP1-mediated synaptic engulfment r
CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr	0.535	neurodegeneration	How do perivascular cells specifically r
Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement F	0.503	synaptic biology	Does SPP1-mediated synaptic engulfment r
TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1	0.496	neurodegeneration	How do perivascular cells specifically r
Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhanc	0.496	neuroinflammation	What molecular mechanisms mediate SPP1-i
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r
Astrocytic SPP1 Modulation via STAT3-Dependent Transcription	0.459	neuroinflammation	What molecular mechanisms mediate SPP1-i
Mitochondrial Damage-Triggered SPP1 Inflammasome Coupling	0.453	neuroinflammation	What molecular mechanisms mediate SPP1-i
Astrocytic SPP1 Modulation for Neuroinflammatory Resolution	0.447	neuroinflammation	What molecular mechanisms mediate SPP1-i
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r
Source-Specific SPP1 Inhibition: Perivascular Cell Targeting	0.429	synaptic biology	Does SPP1-mediated synaptic engulfment r
P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to S	0.423	neurodegeneration	How do perivascular cells specifically r
Partial Agonist/SPP1 Splice Variant Strategy: Splice-Switchi	0.311	synaptic biology	Does SPP1-mediated synaptic engulfment r
CD33-Dependent Switch Hypothesis: CD33 Antagonism Redirects	0.000	synaptic biology	Does SPP1-mediated synaptic engulfment r

Mentioning Analyses (4)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 7 hypotheses Top: 0.752

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

synaptic biology | 2026-04-07 | 8 hypotheses Top: 0.753

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-06 | 7 hypotheses Top: 0.740

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
SPP1 upregulation in perivascular cells in AD mouse models	exploratory	Alzheimer's disease	0.900	AD mouse models	proposed	N/A
Spp1 knockout prevents synaptic loss in AD mouse models	validation	Alzheimer's disease	0.900	Spp1 knockout AD mouse models	proposed	N/A
Single-cell RNA sequencing of microglial states in AD hippocampus	exploratory	Alzheimer's disease	0.850	AD mouse hippocampus	proposed	N/A
Cell-cell interaction analysis of perivascular-microglial crosstalk	exploratory	Alzheimer's disease	0.800	AD mouse models	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

The study shows SPP1 from perivascular cells drives microglial synaptic engulfme

closed · Rounds: 4 · Score: 0.70 · 2026-04-22

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

While SPP1 absence prevents synaptic loss, it's unclear whether this represents

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

closed · Rounds: 5 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning PP1 in their description or question text

Complement Cascade Specificity: Microglial C3aR Antagonism Downstream of SPP1

Score: 0.618 · synaptic biology · 2026-04-21

## Mechanistic Overview Complement Cascade Specificity: Microglial C3aR Antagonism Downstream of SPP1 starts from the cl

LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasome Activation and SPP

Score: 0.617 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The proposed LRP1/NLRP3/IL-1β cascade represents a critical mechanistic link betw

Temporal NLRP3 Inhibition During SPP1-Driven Microglial Activation Windows

Score: 0.551 · neuroinflammation · 2026-04-20

## Mechanistic Overview Temporal NLRP3 Inhibition During SPP1-Driven Microglial Activation Windows starts from the claim

Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control

Score: 0.551 · neuroinflammation · 2026-04-20

## Mechanistic Overview Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control starts from the claim

Synaptic Vulnerability Window Temporal Targeting: Transient SPP1 Blockade

Score: 0.536 · synaptic biology · 2026-04-21

## Mechanistic Overview Synaptic Vulnerability Window Temporal Targeting: Transient SPP1 Blockade starts from the claim

CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering

Score: 0.535 · neurodegeneration · 2026-04-22

## Mechanistic Overview CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering NF-κB-Dependent

Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement Followed by Late Inhi

Score: 0.503 · synaptic biology · 2026-04-21

## Mechanistic Overview Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement Followed by Late Inhibition starts fr

TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through

Score: 0.496 · neurodegeneration · 2026-04-22

## Mechanistic Overview TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through CSF1R-Mediated

Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhancement During Critica

Score: 0.496 · neuroinflammation · 2026-04-21

## Mechanistic Overview Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhancement During Critical Neuroinflammat

YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in Pe

Score: 0.492 · neurodegeneration · 2026-04-22

## Mechanistic Overview YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in Perivascular Fibro

Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control

Score: 0.459 · neuroinflammation · 2026-04-21

## Mechanistic Overview Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control starts from the claim tha

Mitochondrial Damage-Triggered SPP1 Inflammasome Coupling

Score: 0.453 · neuroinflammation · 2026-04-21

## Mechanistic Overview Mitochondrial Damage-Triggered SPP1 Inflammasome Coupling starts from the claim that modulating

Astrocytic SPP1 Modulation for Neuroinflammatory Resolution

Score: 0.447 · neuroinflammation · 2026-04-21

## Mechanistic Overview Astrocytic SPP1 Modulation for Neuroinflammatory Resolution starts from the claim that modulatin

RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivasc

Score: 0.442 · neurodegeneration · 2026-04-22

## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts

Source-Specific SPP1 Inhibition: Perivascular Cell Targeting

Score: 0.429 · synaptic biology · 2026-04-21

## Mechanistic Overview Source-Specific SPP1 Inhibition: Perivascular Cell Targeting starts from the claim that modulati

PP1

Understanding Entity Pages

Summary

Wiki Pages (20)

PPP1R15B

Osteopontin (SPP1)

PPP1R1A (DARPP-32)

PPP1R9A Gene

SPP1 Gene

PPP1R7 — SDS22 (Protein Phosphatase 1 Regulatory Subunit 7)

PPP1R2 Gene

Neurabin-1 (PPP1R18)

PPP1CC Gene - Protein Phosphatase 1 Catalytic Subunit Gamma

Spinophilin (PPP1R9B)

Ceroid Lipofuscinosis 2 (TPP1)

PPP1R9B — Spinophilin

PPP1R15A Gene

PPP1R1B Gene

TPP1 Protein (Tripeptidyl Peptidase 1)

TPP1 Gene - Tripeptidyl Peptidase 1

PP1 Protein

PPP1R15A Protein (GADD34)

PPP1CB Gene

PPP1CA Protein (Protein Phosphatase 1 Alpha)

Pathway Diagram

Outgoing (1)

Incoming (1)

Targeting Hypotheses (23)

Mentioning Analyses (4)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

How do perivascular cells specifically recognize and respond to amyloid-β to upr

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Experiments (4)

Related Papers (0)

Debates (4)

The study shows SPP1 from perivascular cells drives microglial synaptic engulfme

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

While SPP1 absence prevents synaptic loss, it's unclear whether this represents

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Related Research

Complement Cascade Specificity: Microglial C3aR Antagonism Downstream of SPP1

LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasome Activation and SPP

Temporal NLRP3 Inhibition During SPP1-Driven Microglial Activation Windows

Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control

Synaptic Vulnerability Window Temporal Targeting: Transient SPP1 Blockade

CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering

Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement Followed by Late Inhi

TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through

Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhancement During Critica

YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in Pe

Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control

Mitochondrial Damage-Triggered SPP1 Inflammasome Coupling

Astrocytic SPP1 Modulation for Neuroinflammatory Resolution

RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivasc

Source-Specific SPP1 Inhibition: Perivascular Cell Targeting