| Gene Symbol | Secreted Phosphoprotein 1 (Osteopontin) |
| Chromosome | 4q21.1 |
| Function | encodes a secreted matricellular glycoprotein that functions as a cytokine, chemokine, and extracellular matrix protein. |
| Amino Acids | 314 aa |
| Pathways | Amyloid, Angiogenesis, Apoptosis, Complement, Immune Response |
| UniProt ID | P08421 |
| NCBI Gene ID | 6696 |
| Ensembl ID | ENSG00000118733 |
| OMIM | 166490 |
| Associated Diseases | AD, Als, Alzheimer, Alzheimer's disease, Cancer, Carcinoma |
| Known Drugs/Compounds | amyloid-beta oligomers, Bap, BaP, rapamycin, ursolic acid |
| Interactions | ABCA1, Actin, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE |
| SciDEX Hypotheses | Temporal SPP1 Inhibition During Critical Windows PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Medi LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to I (+11 more) |
| KG Connections | 467 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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