concept

PI3K-AKT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K-AKT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

1Hypotheses

0Analyses

21Outgoing

10Incoming

1Experiments

0Debates

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💡 Concept Info

Name	PI3K-AKT
Key Genes/Proteins	AKT, GABARAPL1, GPR34, MAP1LC3
Related Diseases	Alzheimer's disease, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    PI3K_AKT["PI3K-AKT"]
    PI3K_AKT -->|"activates"| MTOR["MTOR"]
    PI3K_AKT -->|"downregulates"| GABARAPL1["GABARAPL1"]
    PI3K_AKT -->|"mediates"| Cholesterol_Efflux["Cholesterol Efflux"]
    PI3K_AKT -->|"activates"| ZEB1["ZEB1"]
    PI3K_AKT -->|"activates"| SNAI1["SNAI1"]
    PI3K_AKT -->|"involved_in"| Cervical_Spondylotic_Myelopath["Cervical Spondylotic Myelopathy"]
    PI3K_AKT -->|"regulates"| apoptosis["apoptosis"]
    PI3K_AKT -->|"regulates"| cell_proliferation["cell proliferation"]
    P2RY12["P2RY12"] -->|"activates"| PI3K_AKT
    NTN1["NTN1"] -->|"activates"| PI3K_AKT
    NFE2L2["NFE2L2"] -->|"upstream_of"| PI3K_AKT
    ROS["ROS"] -->|"modulates"| PI3K_AKT
    ginsenosides["ginsenosides"] -->|"modulates"| PI3K_AKT
    natural_products["natural products"] -->|"activates"| PI3K_AKT

Outgoing (21)

Target	Relation	Type	Str
ALS	involved_in	disease	0.92
PARKINSON'S DISEASE	involved_in	disease	0.92
ALZHEIMER'S DISEASE	involved_in	disease	0.92
microglia activation	activates	process	0.90
MTOR	activates	entity	0.90
GABARAPL1	downregulates	protein	0.90
MICROGLIA	activates	cell_type	0.90
microglia activation	drives	process	0.85
ZEB1	activates	gene	0.85
SNAI1	activates	gene	0.85
cholesterol efflux	associated_with	process	0.85
ALZHEIMER'S DISEASE	involved_in	disease	0.85
Cholesterol Efflux	mediates	process	0.85
MAP1LC3	regulates	protein	0.85
Alzheimer's disease	implicated_in	disease	0.80
Cervical Spondylotic Myelopathy	involved_in	disease	0.75
apoptosis	regulates	process	0.70
cell proliferation	regulates	process	0.70
Parkinson's disease	associated_with	disease	0.70
neuronal survival	activates	process	0.70
neurotoxicity	regulates	process	0.70

Incoming (10)

Source	Relation	Type	Str
P2RY12	activates	entity	0.90
NTN1	activates	entity	0.90
NFE2L2	upstream_of	gene	0.85
AKT	part_of	gene	0.80
TIM-3	impairs	protein	0.80
M1	activates	compound	0.80
GPR34	activates	gene	0.80
ginsenosides	modulates	drug	0.78
natural products	activates	drug	0.70
BP3	impacts	compound	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.718	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing of microglial states in AD hippocampus	exploratory	Alzheimer's disease	0.850	0.00	AD mouse hippocampus	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K-AKT in their description or question text

No additional research found