M1
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about M1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AI-generated illustration
Regenerate portrait ↻Wiki Pages (20)
Knowledge base pages for this entity
SQSTM1 — Sequestosome 1 (p62)
gene · 3742 wordsKRIT1 — Krev Interaction Trapped 1 (CCM1)
gene · 3621 wordsAIFM1 Gene
gene · 3251 wordsAP2M1 Gene
gene · 3193 wordsTMEM175 Protein
protein · 2968 wordsOutgoing (1)
| Target | Relation | Type | Str |
|---|---|---|---|
| PI3K-AKT | activates | pathway | 0.80 |
Incoming (1)
| Source | Relation | Type | Str |
|---|---|---|---|
| TLR4 | activates | protein | 0.70 |
Targeting Hypotheses (6)
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D | 0.698 | neurodegeneration | What is the molecular mechanism by which |
| TREM2 Agonism Has Narrow Early-Window at DAM1→DAM2 Transitio | 0.668 | neurodegeneration | What is the optimal therapeutic window f |
| M1 Muscarinic Receptor Agonism as Pharmacological Exercise S | 0.589 | neurodegeneration | What are the specific circulating factor |
| NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitopha | 0.578 | neurodegeneration | How do different organelle-specific auto |
| Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internaliz | 0.550 | neuroscience | Trans-synaptic tau spreading and propaga |
| GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ | 0.465 | lipidomics | Lipid metabolism dysregulation in Alzhei |
Mentioning Analyses (2)
Scientific analyses that reference this entity
What determines the spatial organization of autophagy receptors at stress granul
neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.633
Lipid metabolism dysregulation and membrane integrity in Alzheimer disease
neurodegeneration | 2026-04-04 | 0 hypotheses
Experiments (0)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Related Papers (0)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Debates (2)
Multi-agent debates referencing this entity
SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout
closed · Rounds: 4 · Score: 0.69 · 2026-04-21
How do alterations in brain lipid metabolism—including gangliosides, phospholipi
closed · Rounds: 4 · Score: 0.84 · 2026-04-11
Related Research
Hypotheses and analyses mentioning M1 in their description or question text