concept

GPR34

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPR34: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

14Outgoing

4Incoming

0Experiments

0Debates

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💡 Concept Info

Name	GPR34
Key Genes/Proteins	AKT
Related Diseases	multiple sclerosis
Related Pathways	ERK, oxidative stress response, PI3K, PI3K-AKT, PI3K-AKT-mTOR signaling

Pathway Diagram

graph TD
    GPR34[GPR34]
    GPR34 -->|promotes| neuroinflammation[neuroinflammation]
    GPR34 -->|activates| PI3K[PI3K]
    GPR34 -->|activates| PI3K_AKT[PI3K-AKT]
    GPR34 -->|activates| ERK[ERK]
    GPR34 -->|expressed in| oligodendrocytes[oligodendrocytes]
    GPR34 -->|expressed in| microglia[microglia]
    LYSOPS[LYSOPS] -->|activates| GPR34
    AKT[AKT] -->|activates| GPR34
    ERK -->|activates| GPR34

Outgoing (14)

Target	Relation	Type	Str
neuroinflammation	promotes	process	0.90
ERK	activates	pathway	0.80
PI3K	activates	pathway	0.80
PI3K-AKT	activates	pathway	0.80
neuroinflammation	senses	process	0.80
neuroinflammation	regulates	disease	0.60
neuroinflammation	activates	disease	0.60
neuroinflammation	inhibits	disease	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
multiple sclerosis	inhibits	disease	0.60
oxidative stress response	participates_in	pathway	0.60
multiple sclerosis	activates	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60

Incoming (4)

Source	Relation	Type	Str
LYSOPS	activates	compound	0.90
LYSOPS	senses	compound	0.80
ERK	activates	gene	0.60
AKT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GPR34 in their description or question text

No additional research found