| Gene Symbol | PGC |
| Full Name | 1 Alpha |
| Aliases | PPARGC1APROTEIN |
| Target Class | Transcription Factor |
| Function | Pgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Mechanism of Action | Small molecule modulator of transcriptional coactivator function |
| Subcellular Localization | | Nucleus, Mitochondrion |
| Druggability | Low (0.43) |
| Clinical Stage | Approved |
| GeneCards | PGC |
| Human Protein Atlas | PGC |
| Associated Diseases | Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, athletic_performance |
| Known Drugs/Compounds | Aloe-emodin, glitazones, Kaixinsan, Lactiplantibacillus plantarum SG5, metformin, METFORMIN |
| Interactions | AKT1, ALS, AMPK, amyloid beta, amyloid-beta, amyotrophic lateral sclerosis |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Perforant Path Presynaptic Terminal Protection Str PGC1α Activation in PV+ Interneurons Bypasses Mito |
| KG Connections | 973 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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