gene 1,179 words KG: PUM1
Contents

OTULIN-Tau Regulation Pathway

🧬 Gene Info
Gene SymbolOTULIN
Full NameTau Regulation Pathway
AliasesOTU Deubiquitinase with Linear Linkage Specificity
Chromosome5p15.2
Protein TypeProtease
FunctionUnlike other OTU family members, OTULIN shows exceptional specificity for linear ubiquitin chains and does not efficiently cleave other ubiquitin linkage types.
PathwaysNF-κB signaling, NF-κB Signaling, NF-κB
Ensembl IDENSG00000135547
GeneCardsOTULIN
Human Protein AtlasOTULIN
SHARPINThe scaffolding subunit
Associated DiseasesInfection, Inflammation
InteractionsIKBKG, INFLAMMATION, MITOCHONDRIA, NFKB, NF-ΚB, PINK1
KG Connections38 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63

Related Analyses (11)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (4)

Neurodegeneration
disease · KG edge: implicated_in
TLR4 (Redirect)
redirect · KG edge: inhibits
KCNK3 Gene
gene · KG edge: downregulates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits

Knowledge Graph (12 edges)

KCNK3 regulates PUM1
HIF1α upregulates PUM1
PUM1 downregulates KCNK3
PUM1 inhibits TLR4
DAB1 implicated_in PUM1
FGF14 implicated_in PUM1
NPTX1 implicated_in PUM1
PLD3 implicated_in PUM1
PUM1 implicated_in STUB1
AND inhibits PUM1

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