gene

NDUFV2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFV2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

12Outgoing

5Incoming

0Experiments

0Debates

Summary

NDUFV2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Cancer, Lung Cancer. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NDUFV2
Full Name	NADH:Ubiquinone Oxidoreductase Core Subunit V2
Chromosome	25p13
Protein Type	Oxidoreductase
Function	encodes a core subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase).
Primary Expression	brain tissue: - High expression in cerebral cortex - High expression in basal ganglia - Expressed in [neurons](/entities/neur
UniProt ID	[P23378](https://www.uniprot.org/uniprot/P23378)
Ensembl ID	ENSG00000170921
GeneCards	NDUFV2
Human Protein Atlas	NDUFV2
Complex I deficiency	Documented in PD substantia nigra
Oxidative stress	Increased ROS from electron leak
Dopaminergic neuron vulnerability	Energy deficit contributes to death
Associated Diseases	Cancer, Lung Cancer
KG Connections	17 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDUFV2 Gene

gene · 558 words

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Pathway Diagram

graph TD
    NDUFV2["NDUFV2"]
    Cancer{"Cancer"}
    NDUFV2 -->|"associated_with"| Cancer
    Lung_Cancer{"Lung Cancer"}
    NDUFV2 -->|"associated_with"| Lung_Cancer
    CANCER(["CANCER"])
    NDUFV2 -->|"associated_with"| CANCER
    LC3B(["LC3B"])
    NDUFV2 -->|"associated_with"| LC3B
    NADH(["NADH"])
    NDUFV2 -->|"associated_with"| NADH
    AUTOPHAGY(["AUTOPHAGY"])
    NDUFV2 -->|"associated_with"| AUTOPHAGY
    MAP1LC3C(["MAP1LC3C"])
    MAP1LC3C -->|"associated_with"| NDUFV2
    ROS(["ROS"])
    ROS -->|"associated_with"| NDUFV2
    ATG14(["ATG14"])
    ATG14 -->|"associated_with"| NDUFV2
    style NDUFV2 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (12)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFV2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cancer	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
AUTOPHAGY	associated_with	gene	0.60
Epithelial-Mesenchymal Transition	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
MAP1LC3A	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
NADH	associated_with	gene	0.60

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFV2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ROS	associated_with	gene	0.60
MAP1LC3C	associated_with	gene	0.60
ATG14	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFV2 in their description or question text

No additional research found