gene

MAP1LC3C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

13Outgoing

0Incoming

0Experiments

0Debates

Summary

MAP1LC3C (Microtubule-Associated Protein 1 Light Chain 3 Gamma) - Autophagy-related protein involved in autophagosome formation, selective mitophagy, and ER-phagy. Risk variants associated with Parkinson's disease and NBIA.

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🧬 Gene Info

Gene Symbol	MAP1LC3C
Full Name	Microtubule-Associated Protein 1 Light Chain 3 Gamma
Chromosome	4q26
Function	MAP1LC3C encodes one of the microtubule-associated proteins (MAP1) light chain 3 family, also known as LC3C
Primary Expression	various tissues with notable expression in: - Brain (cerebral cortex, hippocampus, [cerebellum]
UniProt ID	[Q9GZU8](https://www.uniprot.org/uniprot/Q9GZU8) Category
Ensembl ID	ENSG00000143153
OMIM	609459
GeneCards	MAP1LC3C
Human Protein Atlas	MAP1LC3C
Associated Diseases	Cancer, Lung Cancer
KG Connections	13 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAP1LC3C Gene

gene · 682 words

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Pathway Diagram

graph TD
    MAP1LC3C["MAP1LC3C"]
    Cancer{"Cancer"}
    MAP1LC3C -->|"associated_with"| Cancer
    Lung_Cancer{"Lung Cancer"}
    MAP1LC3C -->|"associated_with"| Lung_Cancer
    ROS(["ROS"])
    MAP1LC3C -->|"associated_with"| ROS
    ATG14(["ATG14"])
    MAP1LC3C -->|"associated_with"| ATG14
    NDUFV2(["NDUFV2"])
    MAP1LC3C -->|"associated_with"| NDUFV2
    CANCER(["CANCER"])
    MAP1LC3C -->|"associated_with"| CANCER
    style MAP1LC3C fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (13)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
MAP1LC3A	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
ROS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
NADH	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Epithelial-Mesenchymal Transition	associated_with	pathway	0.60
ATG14	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
NDUFV2	associated_with	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP1LC3C in their description or question text

No additional research found