Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Glycocalyx: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Sepsis | biomarker_for | disease | 0.92 |
| vascular permeability | regulates | phenotype | 0.90 |
| Sepsis | therapeutic_target | disease | 0.88 |
| leukocyte adhesion | regulates | process | 0.85 |
| microvascular thrombosis | protects_against | phenotype | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MMP | degrades | enzyme | 0.95 |
| HPSE | degrades | enzyme | 0.95 |
| MMP9 | degrades | protein | 0.90 |
| Hyaluronic_Acid | degrades | compound | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat | 0.705 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Glial Glycocalyx Remodeling Therapy | 0.649 | neurodegeneration | 4R-tau strain-specific spreading pattern |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| E2F coordination of G2/M transcriptional program | exploratory | 0.750 | 0.00 | endocycling mammalian cells | proposed | N/A | |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $130,000 |
| Vascular Contribution to Alzheimer's Disease — Beyond Amyloid | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Vascular Contributions to Alzheimer Disease and Mixed Pathology | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic sc [PMID:38448448] | Yang ZR, Suo H, Fan JW, Lv N, Du K, Ma T | Nat Commun | 2024 | 1 |
| NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] | Fei Y, Huang X, Ning F, Qian T, Cui J, W | Biomed Pharmacother | 2024 | 1 |
| The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p [PMID:39149513] | Samaržija I, Lukiyanchuk V, Lončarić M, | Front Cell Dev Biol | 2024 | 1 |
| Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286] | Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei | Respir Res | 2021 | 1 |
| APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans. [PMID:34433968] | Tsiantoulas D, Eslami M, Obermayer G, Cl | Nature | 2021 | 1 |
| The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825] | Uchimido R, Schmidt EP, Shapiro NI | Crit Care | 2019 | 1 |
| Interactions between the products of the Herpes simplex genome and Alzheimer's d [PMID:18164103] | Carter CJ | Neurochem Int | 2008 | 1 |
| Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009] | Yıldırım MA, Korkmaz S, Çelik HHA, Büyük | Cutis | 2026 | 0 |
| CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134] | Odendaal J, Fishwick K, Correia GDS, Lee | Human reproduction (Oxford, En | 2026 | 0 |
| [Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411] | Yin XY, Zhao ZH, Wang Y, Cai N, Chen S | Zhongguo dang dai er ke za zhi | 2026 | 0 |
| Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425] | Alagarasu K, Gurav YK, Pulinchani A, Bac | Journal of medical virology | 2026 | 0 |
| Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595] | Mathis S, Putzer G, Gasteiger L, Staier | Transplant international : off | 2026 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| The interaction of endorepellin and neurexin triggers neuroepithelial autophagy [PMID:38702277] | Lu L, Bai M, Zheng Y, Wang X, Chen Z, Pe | Science bulletin | 2024 | 0 |
| Diverse and multifunctional roles for perlecan (HSPG2) in repair of the interver [PMID:39081381] | Melrose J, Guilak F | JOR spine | 2024 | 0 |
| Spatial transcriptomics reveal markers of histopathological changes in Duchenne [PMID:37582915] | Heezen LGM, Abdelaal T, van Putten M, Aa | Nature communications | 2023 | 0 |
| Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effe [PMID:33544062] | ["Rodr\u00edguez M", "Pintado C", "Torri | Nutritional neuroscience | 2022 | 0 |
| Effects of different types of land-use on taxonomic and functional diversity of [PMID:33847890] | ["Liu Z", "Li Z", "Castro D", "Tan X", " | Environmental science and poll | 2021 | 0 |
| Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through [PMID:31393853] | ["Parimon T", "Yao C", "Habiel D", "Ge L | JCI insight | 2019 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Glycocalyx in their description or question text
No additional research found