Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MBNL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Muscleblind-like 2 (MBNL2) is an RNA-binding protein that regulates alternative splicing in the brain, implicated in myotonic dystrophy, ALS, and Alzheimer's disease.
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| Gene Symbol | MBNL2 |
| Function | Through these domains, MBNL2 binds to pre-mRNA and regulates the alternative splicing of numerous neuronal transcripts[@sinha2020]. |
| Ensembl ID | ENSG00000128591 |
| GeneCards | MBNL2 |
| Human Protein Atlas | MBNL2 |
| Neuronal nitric oxide synthase (nNOS) | Alternative splicing controlled by MBNL2 affects nitric oxide signaling |
| CLN3 and other neuronal transcripts | MBNL2 influences splicing of genes involved in lysosomal function |
| Cerebral cortex | particularly layer 2/3 pyramidal neurons |
| Hippocampus | CA1 region and dentate gyrus granule cells |
| Cerebellum | Purkinje cells and granule cell layer |
| Substantia nigra | dopaminergic neurons |
| Brainstem | various nuclei |
| Nucleus | where it performs splicing functions |
| Cytoplasm | associated with RNA granules |
| Synaptic compartments | present in dendritic spines |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | AND, DMPK, MBNL1, Proteins, RNA |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["MBNL2"]
N1["RNA"]
N0 -->|"interacts with"| N1
N2["DMPK"]
N0 -->|"interacts with"| N2
N3["MBNL1"]
N0 -->|"interacts with"| N3
N4["AND"]
N0 -->|"interacts with"| N4
N3 -->|"interacts with"| N0
N1 -->|"interacts with"| N0
N2 -->|"interacts with"| N0
N5["Proteins"]
N0 -->|"interacts with"| N5
N6["neurodegeneration"]
N0 -->|"implicated in"| N6
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
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class N5 proteinHypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MBNL2 in their description or question text
No additional research found