concept

LEWY BODIES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LEWY BODIES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

17Outgoing

32Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LEWY BODIES
Key Genes/Proteins	ALPHA-SYNUCLEIN, AMYLOID, LRRK2
Related Diseases	CELL DEATH, DEMENTIA, DOPAMINE, NEURODEGENERATION, NEUROINFLAMMATION

Pathway Diagram

graph TD
    LEWY_BODIES["LEWY BODIES"]
    LEWY_BODIES -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    LEWY_BODIES -->|"produces"| CELL_DEATH["CELL DEATH"]
    SNCA["SNCA"] -.biomarker for.-> LEWY_BODIES
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"component_of"| LEWY_BODIES
    Alpha_Synuclein["Alpha-Synuclein"] -->|"involved_in"| LEWY_BODIES
    __synuclein["alpha-synuclein"] -->|"involved_in"| LEWY_BODIES
    LRRK2["LRRK2"] -->|"involved_in"| LEWY_BODIES

Outgoing (17)

Target	Relation	Type	Str
Neurodegeneration	associated_with	process	0.85
AMYLOID	protects_against	protein	0.70
AMYLOID	regulates	protein	0.70
AMYLOID	treats	protein	0.70
PARKINSON'S DISEASE	interacts_with	disease	0.65
CELL DEATH	produces	phenotype	0.65
LRRK2	interacts_with	gene	0.65
ALPHA-SYNUCLEIN	phosphorylates	protein	0.65
NEURODEGENERATION	causes	phenotype	0.65
NEURONS	produces	cell_type	0.65
ALPHA-SYNUCLEIN	interacts_with	protein	0.65
DOPAMINE	expressed_in	phenotype	0.55
NEURODEGENERATION	expressed_in	phenotype	0.55
PARKINSON'S DISEASE	expressed_in	disease	0.55
CORTEX	associated_with	brain_region	0.50
BRAINSTEM	associated_with	brain_region	0.50
THALAMUS	associated_with	brain_region	0.45

Incoming (32)

Source	Relation	Type	Str
SNCA	part_of	gene	1.00
SNCA	biomarker_for	protein	0.98
Alpha-Synuclein	associated_with	protein	0.95
Α-SYNUCLEIN	component_of	protein	0.95
ALPHA-SYNUCLEIN	component_of	protein	0.95
SNCA	associated_with	protein	0.95
alpha-synuclein	associated_with	protein	0.95
SNCA	causes	protein	0.95
HDAC6	component_of	protein	0.90
α-synuclein	involved_in	protein	0.90
α-synuclein	contributes_to	protein	0.80
LRRK2	involved_in	protein	0.80
alpha-synuclein	associated_with	protein	0.80
SORL1	transports	gene	0.65
TAU	interacts_with	protein	0.65
TH	activates	gene	0.65
DEMENTIA	regulates	disease	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
ROS	activates	phenotype	0.65
SNCA	contributes_to	gene	0.60
SORL1	expressed_in	gene	0.55
ALPHA-SYNUCLEIN	expressed_in	protein	0.55
ALPHA-SYNUCLEIN	participates_in	protein	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
CEREBRAL CORTEX	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
VCP	associated_with	gene	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45
CAUDATE NUCLEUS	associated_with	brain_region	0.45
LOCUS COERULEUS	associated_with	brain_region	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
OLFACTORY BULB	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LEWY BODIES in their description or question text

No additional research found